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Medical reviewer

Ania M. Jastreboff, MD, PhD

Harvey and Kate Cushing Professor of Medicine at Yale School of Medicine. Founding director of the Yale Obesity Research Center.

Ania M. Jastreboff, MD, PhD

Medical reviewer

Cushing Professor of Medicine at Yale School of Medicine. Founding director of the Yale Obesity Research Center. Lead investigator on the pivotal retatrutide, tirzepatide and maridebart cafraglutide trials.

Education and training

StageInstitutionYear
BA, Art History (music minor), magna cum laudeBucknell University1998
MDUniversity of Maryland at Baltimore2002
Residency, Internal Medicine / PediatricsUniversity of Maryland School of Medicine2006
Dual fellowship, Adult and Pediatric EndocrinologyYale School of Medicine2011
PhD, Investigative MedicineYale Graduate School2012

Board certifications

Board certified in five specialties: internal medicine, pediatrics, endocrinology/diabetes/metabolism, pediatric endocrinology, and obesity medicine.

Current positions

  • Harvey and Kate Cushing Professor of Medicine (Endocrinology), Yale School of Medicine
  • Professor of Pediatrics (Endocrinology)
  • Founding Director, Yale Obesity Research Center (Y-Weight)
  • Co-Director, Yale Center for Weight Management

Research areas

Obesity pharmacotherapy; nutrient-stimulated hormone (NuSH)-based therapies; the neurobiology underlying obesity studied with fMRI and PET neuroimaging; mechanisms of action of anti-obesity medications; large multicentre clinical outcomes trials.

112 publications, 12,422 citations.

Lead investigator on landmark trials

All published in the New England Journal of Medicine:

  • Tirzepatide (dual GIP/GLP-1 receptor agonist), SURMOUNT programme, NEJM 2022 and 2024
  • Retatrutide (triple GIP/GLP-1/glucagon receptor agonist), NEJM 2023
  • Maridebart cafraglutide / MariTide (GIP receptor antagonist / GLP-1 receptor agonist), NEJM 2025

Book

Enough: Your Health, Your Weight, and What It's Like To Be Free co-authored with Oprah Winfrey. Simon & Schuster, January 2026. #1 National Bestseller.

Awards

The Obesity Society Clinician of the Year (2023), NIH/NIDDK K23 Mentored Patient-Oriented Research Career Development Award (2014), New York Times Best-Selling Author (2026).